There's a very polarizing topic amongst musicians, especially guitar players: Cable or wireless? 
When I say polarizing, I mean there are people who will die on a hill for either one of them. There are players who are STRICTLY cable and those who are well adjusted. Okay, calm down. I was only joking (maybe). I, myself, view it as completely situational. It depends on which is more important at that given time; convenience or tone. Let's take a closer look into this, shall we?

CABLE: Because technology is sorcery/witchcraft/work of Voldemort. 
Cable-only players will hit you with a ton of reasons they'll NEVER use wireless; ranging from it negatively affecting tone to hating the feeling of a wireless pack on their back. These people are the most difficult to convince. Stalwarts, through and through. Never mind they almost kill or maim themselves almost every night by moving around and getting wrapped and trapped by their 50' cable around their feet. Never mind that most musicians don't have medical insurance. Never mind most musicians and punters are either too deaf or drunk/high on chemicals to tell the difference. 

TONE IS IMPORTANT, DAMMIT! (I'm sorry, was that too cynically biased? My apologies; I've had sugar today.) 

I'm not saying it's all malarkey. 

A cable can make or break a good guitar sound; ESPECIALLY under the aural microscope of a recording studio, where a tea kettle 2 rooms away is picked up by microphones. In a studio, signal path is CRUCIAL. So, guitar -> cable -> amplifier gives you the purest signal to start with, then any tone crafting afterward is as clean and clear as can be. But in a live situation, does it really matter? Some say it does, and swear to that. 

And then there's those filthy, lazy, lackadaisical, techno freaks who DARE to use... 

WIRELESS: Because it's the future, grandpa! And, like, get up to date, boomer. Gosh, you're so old. And, freedom and such!!  Can't hold me back, w00t!! 

As someone who recently joined the wireless club, I must say that I wish I had joined sooner. I'm late to the party, not because of apprehension, but simply lack of knowledge (and funds). There's a ton of different brands and styles of wireless units, and they can be a bit pricey to go and try them all out to find what's best for you. But once you do find the right one, it's kind of hard to go back to cable. Some wireless units process your signal in pretty cool ways. Some add compression and gain to your signal; helping you drive the preamp a little harder and get more crunch from your amp. 
 

A great example is the Schaffer/Vega Diversity System of the late 70's/early 80's. Angus Young of AC/DC and the late, great King Edward Van Halen liked what their wireless units did to their overall tone, they used them in the studio on records; 
Go back and listen to "Back in Black". That's the Schaffer-Vega you're hearing. The technology has advanced so far past the days of picking up police communications and radio stations through your Marshall stacks. Some even have cable emulators to get closer to the tone of a cable (Cable guy: "WORK OF THE DEVIL!") Also, the transmitter units have copied the cell phone modus operandi and gotten smaller as time has gone by. Gone are the days of being forced to have this pack with a long string antenna; now it's a simple input jack slightly bigger than your finger. We've come a long way since the old days. Biggest selling point: spin around in all the circles you want without risk of hospital visit or medical bills! Ain't nobody got time for medical bills! 

I know this sounds biased and kind of mean-spirited, but I just think we can take this whole cable vs. wireless thing a bit too seriously. Both have a place in the music world, and at the end of the day, to each their own. I'm not here to convince anybody on what they should or shouldn't use. I really aim to encourage anyone who has wanted to experiment with it to do so without feeling like they've betrayed some sacred doctrine or something. Just cool down the arguments, I guess. And, more importantly, don't take sound advice from people who've spent most of their lives in front of speakers blasting volumes loud enough to kill small animals. Not sure their ears can be trusted. 
 

Live LOUD and prosper,